
孙建东 讲师
硕士生导师,组织学与胚胎学系
联系邮箱:jiandongsun12138@fjmu.edu.cn
个人简介
孙建东,男,讲师,硕士生导师。福建医科大学人体解剖与组织胚胎学专业获医学博士学位。现主持福建省联合创新基金、福建医科大学高层次人才科研启动项目各1项。近年来以共同第一作者/共同通讯作者发表SCI论文10篇,其中2区以上论文8篇。指导研究生获福建省基础医学研究生创新大赛学术墙报(博士组)一等奖,指导本科生获福建医科大学基础医学创新论坛暨实验设计大赛三等奖。
研究领域
男性不育与防治
主持/参与的项目
1.国家自然科学基金,Trps1在睾丸间质细胞衰老中的作用机制及抑制剂的发现,30万元,2026.01-2028.12,主持;
2.福建省科技厅,科技创新联合资金,Trps1在成年睾丸间质细胞发育过程中的调控作用及应用研究,15万元,2024.12-2027.12,主持;
3.福建医科大学,福建医科大学高层次人才科研启动基金,组蛋白甲基化在成年睾丸间质细胞生成中的表达模式及作用机制,15万元,2024.12-2027.12,主持。
科研成果
1. Sun J#, Lv C#, Lin Z#, Luo S, Liao S, Lian X, Liu Y, Luo L, Zheng M, Zhang D, Wang X, Wang S*. Integrating network pharmacology and experimental validation to decipher the protective effect of icariin against testicular aging. Ecotoxicol Environ Saf. 2025 Sep 15;303:119063. doi: 10.1016/j.ecoenv.2025.119063. (IF: 6.1,中科院1区)
2. Sun J#, Lian X#, Luo S#, Lin Z, Luo L, Zheng M, Zhang D, Lin Z, Wang X, Wang S*. Dynamic Landscape of H3K4me3 and H3K27me3 Modification During Postnatal Leydig Cell Fate Determination. Andrology. 2025 Dec 22:e70165. doi: 10.1111/andr.70165. (IF: 3.4,中科院1区)
3. Lian X#, Lin Z#, Hu W#, Chen Z, Luo S, Liao S, Liu Y, Wang S*, Sun J*. Trps1 targets Scarb1 to regulate cholesterol acquisition in mouse Leydig cells. Reprod Biol. 2025 Jun 18;25(3):101046. doi: 10.1016/j.repbio.2025.101046. (IF:2.0,中科院3区)
4. Sun J#, Lian X#, Lv C#, Li H, Lin Z, Luo S, Liu Y, Xu Y, Jiang X, Xu W, Liao S, Chen Z, Wang S*. Trps1 acts as a regulator of Sf-1 transcription and testosterone synthesis in mouse Leydig cells. Cell Biol Toxicol. 2023 Dec;39(6):3141-3157. doi: 10.1007/s10565-023-09823-8. (IF:6.1,中科院1区)
5. Sun J#, Li H#, Lv C# Draz E, Liu Y, Lin Z, Hu W, Mo K, Lin J, Xu W, Wang S*. Trps1 targets Ccnd1 to regulate mouse Leydig cell proliferation. Andrology. 2021 Nov;9(6):1923-1933. doi: 10.1111/andr.13072.(IF:4.456,中科院1区)
6. Sun J#, Xu W#, Zheng S#, Lv C, Lin J, Chen S, Qiu Y, Jiang X, Draz E, Wang S*. Icariin promotes mouse Leydig cell testosterone synthesis via the Esr1/Src/Akt/Creb/Sf-1 pathway. Toxicol Appl Pharmacol. 2022 Apr 15;441:115969. doi: 10.1016/j.taap.2022.115969. (IF:3.8,中科院2区)
7. Sun J#, Wang D#, Lin J#, Liu Y, Xu L, Lv R, Mo K, Lian X, Xie M, Xu S, Wang S*. Icariin protects mouse Leydig cell testosterone synthesis from the adverse effects of di(2-ethylhexyl) phthalate. Toxicol Appl Pharmacol. 2019 Sep 1;378:114612. doi: 10.1016/j.taap.2019.114612. (IF:3.347,中科院2区)
8. Lv C#, Lin Z#, Sun J#, Ye Y#, Wu Q, Cai L, Liu D, Sun P*, Wang S*. EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer. Adv Sci (Weinh). 2026 Feb;13(12):e04238. doi: 10.1002/advs.202504238. (IF: 14.1,中科院1区)
9. Wang X, Sun J#, Liu Y, Lin Z, Jiang X, Ye Y, Lv C, Lian X, Xu W, Luo S, Liao S, Chen Z, Wang S*. Trps1 predicts poor prognosis in advanced high grade serous ovarian carcinoma. Int J Cancer. 2024 May 1;154(9):1639-1651. doi: 10.1002/ijc.34844. (IF:6.4,中科院2区TOP)
10. Lv C, Sun J#, Ye Y, Lin Z, Li H, Liu Y, Mo K, Xu W, Hu W, Draz E, Wang S*. Long noncoding RNA EIF1AX-AS1 promotes endometrial cancer cell apoptosis by affecting EIF1AX mRNA stabilization. Cancer Sci. 2022 Apr;113(4):1277-1291. doi: 10.1111/cas.15275. (IF:5.7,中科院2区)
11. Liu Y, Sun J#, Su Y, Lin J, Lv C, Mo K, Xu S, Wang S*. Nuclear-localized eukaryotic translation initiation factor 1A is involved in mouse preimplantation embryo development. J Mol Histol. 2021 Oct;52(5):965-973. doi: 10.1007/s10735-021-10014-0. (IF:3.156,中科院3区)
12. Jiang X, Xu W, Sun J#, Lin J, Lin Z, Lian X, Liao S, Luo S, Liu Y*, Wang S*. Trps1 regulates mouse zygotic genome activation and preimplantation embryo development via the PDE4D/AKT/CREB signaling pathway. Cell Biol Toxicol. 2025 Feb 20;41(1):48. doi: 10.1007/s10565-025-09999-1. (IF: 5.9,中科院1区)
13. Ye Y, Lv C, Sun J#, Lin Z, Liu Y, Huang Y, Chen Y, Li H, Lian X, Jiang X, Zhang S*, Wang S*. XPO1-Mediated EIF1AX Cytoplasmic Relocation Promotes Tumor Migration and Invasion in Endometrial Carcinoma. Oxid Med Cell Longev. 2022 Dec 22;2022:1361135. doi: 10.1155/2022/1361135. (IF: 7.31,中科院2区)
(更新于2026年3月)



